![]() ![]() Diabetic retinopathy - identifying neovascular complexes, and quantifying foveal avascular zone and nonperfused areas, showing good agreement with FA findings.OCT-A has been reported to be useful in the diagnosis and understanding of many retinal conditions, namely: Therefore, only a brief description of current uses is available in this article and further information should be looked in the available ophthalmology journals. The number of studies reporting new findings and utilities is exponentially growing. However, some limitations and artifacts are important to consider in the interpretation of OCT-A images (see section below).Īs a fast, safe and noninvasive procedure to assess the chorioretinal microvasculature, OCT-A has been increasingly used in retinal diseases. Moreover, and contrary to the "2-D" conventional angiograms, OCT-A technology provides "3-D" imaging information of the macula and visualizes peripapillary capillaries that supply the retinal nerve fiber layer. One asset of this OCT-based approach is that it provides a quantitative analysis of the retinal vessels (in addition to the qualitative analysis done on standard angiography). Fluorescein and indocyanine-green angiography require an injectable dye (which takes time to reach retinal vessels, and may be associated with systemic adverse effects and even anaphylatic reactions ). The main advantages are the shorter acquisition time and that it is a non-invasive process. Heidelberg engineering® uses the active eye-tracking system (TruTrack™) that assesses simultaneously fundus and OCT images acquisition in order to achieve a better signal-to-noise ratio.Īdvantages over conventional angiography methods.Topcon® uses a different algorithm, OCTA RatioAnalysis, which benefits from being paired with SD-OCT, and improves detection sensitivity of low blood flow and reduced motion artifacts without compromising axial resolution.This system also allows quantitative analysis, since it provides numerical data about flow area and flow density maps. Optovue AngioVue® (Optovue, Inc., Freemont, CA), which uses split-spectrum amplitude-decorrelation angiography algorithm, which minimizes motion noise.A three-dimensional image is obtained depicting erythrocyte flow as well as the microvasculature of the superficial, deep, and avascular layers of the retina. ZEISS Angioplex™ OCT angiographic imaging on the CIRRUS™ HD-OCT platform, with a scanning rate up to 68,000 A-scans per second and an improved tracking software known as FastTrac™.Above is a single structural OCT b-scan through the center of the angiogram (yellow).Ĭurrently, there are currently 4 main commercially available OCT-A devices : Red-orange appearing vessels comprise the superficial vascular plexus while green appearing vessels comprise the deep capillary plexus. įull thickness color depth-encoded OCT angiogram of a normal eye. Applied to the optic disc it includes its full depth. These OCT-A algorithms produce an image (3mm 2 to 12mm 2) that is segmented, by standard, into four zones: the superficial retinal plexus, the deep retinal plexus, the outer retina and the choriocapillaris. To improve visualization and reduce background noise from normal small eye movements, two averaging methods - split spectrum amplitude decorrelation technique and volume averaging - were developed. Phase variance is related to the emitted light wave properties, and the variation of phase when it intercepts moving objects. The former detects differences in amplitude between two different OCT B-scans. OCT-A employs two methods for motion detection: amplitude decorrelation or phase variance. ![]() Longer wavelengths have a deeper tissue penetrance, but a slightly lower axial resolution. Light is emitted through either a spectral domain OCT (SD-OCT), with a wavelength of near 800nm or a swept-source OCT (SS-OCT), which utilizes a longer wavelength, close to 1050nm. with marked changes between scans) and zones with slower, or no flow at all, which will be similar among scans. With OCT-A technology, the same tissue area is repeatedly imaged and differences are analyzed between scans (over time), thus allowing one to detect zones containing high flow rates (i.e. The OCT scan of a patient's retina consists of multiple individual A-scans, which when compiled into a B-scan provides cross-sectional structural information. OCT-A technology uses laser light reflectance of the surface of moving red blood cells to accurately depict vessels through different segmented areas of the eye, thus eliminating the need for intravascular dyes. The first clinical studies using this innovative technology were published in 2014. Optical coherence tomography angiography (OCT-A) has emerged as a non-invasive technique for imaging the microvasculature of the retina and the choroid. The foveal avascular zone is seen in the center of the macula. OCT angiogram of a normal eye illustrating detailed microvasculature in the macula. ![]()
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